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Keywords and phrases: fibromyalgia; palmitoylethanolamide; melatonin; nutraceuticals; discomfort; rest; quality of life1996). Oral PEA also lessened paw oedema induced by carrageenan, dextran and formalin, suggesting that the compound straight down‐modulates mast mobile activation in vivoOur conclusions thus support the thought of PEA for patient